💧 Kidney Health

慢性肾病:肾功能与健康指标

慢性肾病影响全球数百万人。通过定期血液检查早期发现对于防止进展为肾衰竭至关重要。

Prevalence:15% of U.S. adults (37 million people)

什么是慢性肾病?

慢性肾病(CKD)是肾功能随时间逐渐丧失。肾脏过滤血液中的废物和多余液体。当它们功能不正常时,废物会积累。

关键肾脏指标

eGFR(估算肾小球滤过率)是最重要的指标:≥90为正常,60-89为2期,30-59为3期,15-29为4期,<15为5期(肾衰竭)。

风险因素

主要风险因素包括糖尿病(第一大原因)、高血压(第二大原因)、心脏病、家族史和长期使用某些药物。

预防与肾脏保护

通过控制血压和血糖、保持水分摄入、避免过度使用非甾体抗炎药和定期检查来保护肾脏。

🌍 Regional Context

慢性肾病是一个日益严重的全球健康问题。

中国约有10.8%的成年人患有某种程度的慢性肾病。糖尿病和高血压是主要原因。

数据来源:中华医学会肾脏病学分会。

❓ Frequently Asked Questions

什么eGFR表示肾病?

eGFR持续低于60 mL/min/1.73m²超过3个月表示慢性肾病。

📊 需要监测的关键指标

这些健康指标对于诊断和监测chronic kidney disease (ckd)至关重要:

🔬 Diagnostic Criteria

Healthcare providers use these thresholds to diagnose and classify chronic kidney disease (ckd):

MetricThresholdClassification
eGFR≥90 mL/minStage 1 (Normal/High)
eGFR60-89 mL/minStage 2 (Mild decrease)
eGFR45-59 mL/minStage 3a (Mild-Moderate)
eGFR30-44 mL/minStage 3b (Moderate-Severe)
eGFR15-29 mL/minStage 4 (Severe)
eGFR<15 mL/minStage 5 (Kidney Failure)

Note: Diagnosis requires clinical evaluation. These criteria are for reference only.

⚠️ Risk Factors

Diabetes
High blood pressure
Heart disease
Family history
Age over 60
Obesity
Smoking

🔴 Potential Complications

If left unmanaged, chronic kidney disease (ckd) may lead to:

Fluid retention
Potassium buildup
Cardiovascular disease
Weak bones
Anemia
End-stage kidney disease

✅ Prevention Strategies

1Control blood sugar
2Manage blood pressure
3Maintain healthy weight
4Avoid NSAIDs overuse
5Stay hydrated
6Regular kidney function tests

🧬 Understanding Chronic Kidney Disease (CKD)

Medical Literature

CKD involves progressive nephron loss from various causes. Diabetes and hypertension account for 60%+ of cases, causing glomerular damage. As nephrons are lost, remaining ones hypertrophy and hyperfiltrate, leading to further damage. Proteinuria accelerates progression through tubular toxicity. Declining kidney function causes metabolic abnormalities: uremia, anemia (reduced EPO), bone disease (phosphorus retention, vitamin D deficiency), and cardiovascular complications. The kidneys' role in regulating blood pressure, electrolytes, and acid-base balance makes CKD a systemic disease.

📈 Epidemiology & Statistics

CDC / WHO Data
Global Prevalence
850 million people worldwide have CKD
U.S. Prevalence
37 million Americans (15%) have CKD
Trend
Increasing due to diabetes and aging population
Demographics
Higher in Black and Hispanic populations, increases sharply with age
Data from CDC National Health Statistics, WHO Global Health Observatory, and peer-reviewed epidemiological studies.

🔍 Screening Recommendations

KDIGO/NKF
Recommended Frequency: Annually for those with diabetes, hypertension, or risk factors

Recommended Tests

  • eGFR calculation from serum creatinine
  • Urine albumin-to-creatinine ratio (UACR)
  • Blood pressure measurement
  • Electrolyte panel as CKD progresses
💡 Note: Screening recommendations may vary based on individual risk factors. Consult with your healthcare provider for personalized screening guidance.

💊 Treatment Approaches

Clinical Guidelines

Blood Pressure Control

1

Target <130/80, ACE inhibitors/ARBs preferred

Effectiveness: Slows progression by 30-40%

SGLT2 Inhibitors

2

Kidney protection beyond glucose control

Effectiveness: Reduces kidney failure risk by 30-40%

Dietary Management

3

Protein and sodium restriction as appropriate

Effectiveness: May slow progression

Dialysis/Transplant

4

Renal replacement therapy for ESRD

Effectiveness: Life-sustaining for kidney failure
⚠️ Medical Disclaimer: Treatment decisions should be made with healthcare providers based on individual circumstances, preferences, and the latest clinical evidence.

🔬 Recent Research & Advances

Peer-Reviewed Studies
📄CREDENCE and DAPA-CKD trials: SGLT2 inhibitors slow CKD progression
📄CKD-EPI 2021 equation removed race from eGFR calculation
📄Finerenone (nonsteroidal MRA) shows additional kidney protection
📄Xenotransplantation research advancing
Research in this field is rapidly evolving. These highlights represent recent developments from major clinical trials and peer-reviewed publications.

📊 Understanding Related Metrics

These health metrics play key roles in diagnosing, monitoring, and managing chronic kidney disease (ckd). Understanding what each measures helps you better interpret your results.

eGFR

Role: Primary kidney function measure

View benchmarks →

Creatinine

Role: Waste product indicator

View benchmarks →

BUN

Role: Nitrogen waste level

View benchmarks →

Albumin-Creatinine Ratio

Role: Kidney damage marker

View benchmarks →

Cystatin C

Role: Alternative filtration marker

View benchmarks →

❓ Frequently Asked Questions

What is Chronic Kidney Disease (CKD)?

CKD involves progressive nephron loss from various causes. Diabetes and hypertension account for 60%+ of cases, causing glomerular damage. As nephrons are lost, remaining ones hypertrophy and hyperfiltrate, leading to further damage. Proteinuria accelerates progression through tubular ...

How common is Chronic Kidney Disease (CKD)?

37 million Americans (15%) have CKD

What metrics should I monitor for Chronic Kidney Disease (CKD)?

Key metrics include: eGFR, Creatinine, BUN, Albumin-Creatinine Ratio, Cystatin C. Regular monitoring of these values can help track disease status and treatment response.

How is Chronic Kidney Disease (CKD) diagnosed?

Diagnosis typically involves: eGFR calculation from serum creatinine, Urine albumin-to-creatinine ratio (UACR), Blood pressure measurement. Your healthcare provider will interpret these results in the context of your overall health.

Can Chronic Kidney Disease (CKD) be prevented?

Prevention strategies typically focus on lifestyle modifications and managing risk factors. Early detection through screening is also important.

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